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Article

Prostaglandin E2 Regulates the Nuclear Receptor NR4A2 in Colorectal Cancer

17 Nov 2005

Abstract excerpt

Many lines of research implicate cyclooxygenase 2-derived prostaglandins in tumor growth and metastasis. More specifically, we have shown that prostaglandin E2 (PGE2) promotes cell proliferation and invasion through transactivation of the epidermal growth factor receptor, initiates immune evasion through induction of decay accelerating factor, and transactivates peroxisome proliferator-activated receptor delta,...

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PMID: 16293616
DOI: 10.1074/jbc.m507752200

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