Article
F₁ cross-breed between susceptible BALB/c and resistant Swiss mice infected with Leishmania major exhibit an intermediate phenotype for lesion sizes and type 1 cytokines but show low level of total IgG antibodies.
Scandinavian journal of immunology - 1 May 2014
Kiige S G, Mutiso J M, Laban L T, Khayeka-Wandabwa C, Anjili C O, Ingonga J, Gicheru M M
Abstract excerpt
Our current understanding of the host immune response during leishmaniases largely derives from studies performed in mice due to the intrusive techniques required to study infected human patients. Swiss mice are highly resistant to Leishmania infections in concordance with observed response in humans, while BALB/c mice indicate a high-susceptibility phenotype. Developing a cross-breed between BALB/c and Swiss...
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