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Article

T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects.

Human immunology - 1 May 2001

Cardoso C, Porto G, Lacerda R, Resende D, Rodrigues P, Bravo F, Oliveira J C, Justiça B, de Sousa M

Abstract excerpt

Low CD8(+) T lymphocyte numbers have contributed to deciphering the genotype/phenotype discrepancies found in hereditary hemochromatosis (HH) patients genotyped for the Hfe mutations, C282Y and H63D. In this study, we extend the analysis of T lymphocytes in HH to the T cell receptor (TcR) repertoire. Thirty-two HH patients (C282Y homozygous) and 274 Hfe genotyped healthy subjects were studied. The following TcR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11334672
DOI: 10.1016/s0198-8859(01)00233-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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T-cell receptor repertoire in hereditary hemochromatosis: a study of 32 hemochromatosis patients and 274 healthy subjects.PMID 11334672Read ↗

Low serum transferrin levels in HFE C282Y homozygous subjects are associated with low CD8(+) T lymphocyte numbers.Semantic proximity Read ↗

A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload.Semantic proximity Read ↗

Iron overload in HFE-related hemochromatosis severely impairs Vδ2+ γδ T-cell homeostasisSemantic proximity Read ↗

Relative impact of HLA phenotype and CD4-CD8 ratios on the clinical expression of hemochromatosis.Semantic proximity Read ↗

Peripheral lymphocytes and intracellular cytokines in C282Y homozygous hemochromatosis patients.Semantic proximity Read ↗

Effects of highly conserved major histocompatibility complex (MHC) extended haplotypes on iron and low CD8+ T lymphocyte phenotypes in HFE C282Y homozygous hemochromatosis patients from three geographically distant areas.Semantic proximity Read ↗

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