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Article

TNF-alpha promoter polymorphisms and primary open-angle glaucoma.

Eye (London, England) - 1 Sept 2006

Mossböck G, Weger M, Moray M, Renner W, Haller-Schober E M, Mattes D, Schmut O, Wegscheider B, El-Shabrawi Y

Abstract excerpt

PURPOSE: Primary open-angle glaucoma (POAG) is a multifactorial optic neuropathy with a strong hereditary component. Recent studies suggested a role for tumour necrosis factor-alpha(TNF-alpha) in the pathogenesis of POAG. The purpose of the present study was to investigate a hypothesized association between the TNF-alpha-308G>A and -238G>A gene polymorphisms and the presence of POAG in a Caucasian population....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16138112
DOI: 10.1038/sj.eye.6702078

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TNF-alpha promoter polymorphisms and primary open-angle glaucoma.PMID 16138112Read ↗

Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma.Semantic proximity Read ↗

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Risk of open angle glaucoma due to tumor necrosis factor alpha gene polymorphismsSemantic proximity Read ↗

TNF-alpha -308 G>A and -238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma.Semantic proximity Read ↗

A detailed meta-analysis shows no association between TNF-α -308G/A polymorphism and different forms of glaucoma.Semantic proximity Read ↗

Polymorphism in the TNF-α(-863) locus associated with reduced risk of primary open angle glaucoma.Semantic proximity Read ↗

TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis.Semantic proximity Read ↗

Association of TNFA -308 G/A and TNFRI +36 A/G gene polymorphisms with glaucoma.Semantic proximity Read ↗

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Roles of tumor necrosis factor alpha gene polymorphisms, tumor necrosis factor alpha level in aqueous humor, and the risks of open angle glaucoma: a meta-analysis.Semantic proximity Read ↗

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