Article
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Haas Ulrike, Raschperger Elisabeth, Hamberg Mats, Samuelsson Bengt, Tryggvason Karl, Haeggström Jesper Z
Abstract excerpt
Lipoxygenases (LO) are a class of dioxygenases, which form hydroperoxy, hydroxy, and epoxy derivatives of arachidonic acid with distinct positional and stereochemical configurations. In man, there are two known types of 12-LO that are distinguished by their expression patterns and catalytic properties. The platelet 12S-LO plays a role in platelet aggregation and 12R-LO seems to be important for normal skin...
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