Article
SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity.
Biochemical and biophysical research communications - 8 Oct 2004
Coleman Kevin M, Lam Vinh, Jaber Basem M, Lanz Rainer B, Smith Carolyn L
Abstract excerpt
The ability of steroid receptor RNA activator (SRA), an AF-1 coactivator, to contribute to differences in estrogen receptor (ER)-alpha and ERbeta transcriptional activity was tested. In transient transfections, SRA expression increased ERalpha- and ERbeta-dependent gene expression. However, when the receptors' amino-terminal A/B regions were examined as GAL4 DNA binding domain fusions, SRA enhanced the activity...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.