Article
PI 3-kinase: structural and functional analysis of intersubunit interactions.
The EMBO journal - 1 Feb 1994
Dhand R, Hara K, Hiles I, Bax B, Gout I, Panayotou G, Fry M J, Yonezawa K, Kasuga M, Waterfield M D
Abstract excerpt
Phosphatidylinositol (PI) 3-kinase has an 85 kDa subunit (p85 alpha) which mediates its association with activated protein tyrosine kinase receptors through SH2 domains, and an 110 kDa subunit (p110) which has intrinsic catalytic activity. Here p85 alpha and a related protein p85 beta are shown t...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cattle
- Cell Line
- Electrophoresis, Polyacrylamide Gel
- Glutathione Transferase
- L Cells
- Mice
- Molecular Sequence Data
- Moths
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Restriction Mapping