Gene selective suppression of nonsense termination using antisense agents.

doi:10.1016/j.bbaexp.2005.07.004

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Article

Gene selective suppression of nonsense termination using antisense agents.

Biochimica et biophysica acta - 25 Sept 2005

Kulyté Agné, Dryselius Rikard, Karlsson Jenny, Good Liam

Abstract excerpt

An estimated one third of all inherited genetic disorders and many forms of cancer are caused by premature (nonsense) termination codons. Aminoglycoside antibiotics are candidate drugs for a large number of such genetic diseases; however, aminoglycosides are toxic, lack specificity and show low efficacy in this application. Because translational termination is an active process, we considered that steric...

Topics

Anti-Bacterial Agents
Codon, Nonsense
Dose-Response Relationship, Drug
Escherichia coli
Genes, Bacterial
Genes, Reporter
Genes, Suppressor
Gentamicins
Luciferases
Mutation
Paromomycin
Plasmids
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 16135388
DOI: 10.1016/j.bbaexp.2005.07.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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