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Article

Screening Readthrough Compounds to Suppress Nonsense Mutations: Possible Application to β-Thalassemia

21 Jan 2020

Abstract excerpt

Several types of thalassemia (including β039-thalassemia) are caused by nonsense mutations in genes controlling globin production, leading to premature translation termination and mRNA destabilization mediated by the nonsense mediated mRNA decay. Drugs (for instance, aminoglycosides) can be designed to suppress premature translation termination by inducing readthrough (or nonsense suppression) at the premature...

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PMID: 31972957
DOI: 10.3390/jcm9020289

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