Article
Alcohol dehydrogenase 3, glutathione S-transferase M1 and T1 polymorphisms, alcohol consumption and hepatocellular carcinoma (Italy).
Cancer causes & control : CCC - 1 Sept 2005
Covolo Loredana, Gelatti Umberto, Talamini Renato, Garte Seymour, Trevisi Paola, Franceschi Silvia, Franceschini Michela, Barbone Fabio, Tagger Alessandro, Ribero Maria Lisa, Parrinello Giovanni, Donadon Valter, Nardi Giuseppe, Donato Francesco
Abstract excerpt
OBJECTIVE: The aim of this study was to investigate the role of alcohol dehydrogenase type 3 (ADH3), glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms in modifying hepatocellular carcinoma (HCC) risk according to alcohol intake. METHODS: A hospital-based case-control study was conducted in two areas of North Italy. Two-hundred cases hospitalized for HCC and 400 controls were recruited. Genotypes...
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