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Article

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding.

Alcoholism, clinical and experimental research - 1 Aug 2005

Ji Cheng, Mehrian-Shai Ruty, Chan Christine, Hsu Ya-Hsuan, Kaplowitz Neil

Abstract excerpt

BACKGROUND: CHOP is a transcriptional regulator involved in apoptosis caused by endoplasmic reticulum (ER) stress. We previously reported that CHOP as well as other ER stress response genes is induced in the liver of a murine model of intragastric ethanol feeding. This study was undertaken to determine the role of CHOP in hepatocellular apoptosis and liver injury in this model. METHODS: CHOP wild-type (+/+) mice...

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Source

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Identifiers

PMID: 16131858
DOI: 10.1097/01.alc.0000174691.03751.11
PMCID: PMC1432051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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