Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C/EBP Homologous Protein (CHOP) Contributes to Suppression of Metabolic Genes during Endoplasmic Reticulum Stress in the Liver

2 Jan 2013

Abstract excerpt

The unfolded protein response (UPR) senses stress in the endoplasmic reticulum (ER) and initiates signal transduction cascades that culminate in changes to gene regulation. Long recognized as a means for improving ER protein folding through up-regulation of ER chaperones, the UPR is increasingly recognized to play a role in the regulation of metabolic pathways. ER stress is clearly connected to altered metabolism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Endoplasmic Reticulum Stress and Disease
Share to Lipid metabolism and biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23281479
DOI: 10.1074/jbc.m112.432344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C/EBP Homologous Protein (CHOP) Contributes to Suppression of Metabolic Genes during Endoplasmic Reticulum Stress in the LiverPMID 23281479Read ↗

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and OncogenesisSemantic proximity Read ↗

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Semantic proximity Read ↗

Transcription Factor C/EBP Homologous Protein in Health and DiseasesSemantic proximity Read ↗

Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription FactorsSemantic proximity Read ↗

Differential Control of the CCAAT/Enhancer-binding Protein β (C/EBPβ) Products Liver-enriched Transcriptional Activating Protein (LAP) and Liver-enriched Transcriptional Inhibitory Protein (LIP) and the Regulation of Gene Expression during the Response to Endoplasmic Reticulum StressSemantic proximity Read ↗

CCAAT/Enhancer Binding Protein<b><i>β</i></b>in relation to ER Stress, Inflammation, and Metabolic DisturbancesSemantic proximity Read ↗

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseSemantic proximity Read ↗

New insights into the roles of CHOP-induced apoptosis in ER stressSemantic proximity Read ↗

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and DiseaseSemantic proximity Read ↗

New insights into the roles of CHOP-induced apoptosis in ER stressSemantic proximity Read ↗

Creld2 function during unfolded protein response is essential for liver metabolism homeostasisSemantic proximity Read ↗

Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.