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The ER Stress Pathway Involving CHOP Is Activated in the Lungs of LPS-Treated Mice

1 Oct 2005

Abstract excerpt

CHOP is a C/EBP family transcription factor involved in endoplasmic reticulum (ER) stress-mediated apoptosis. To determine if the ER stress pathway is involved in the pathogenesis of LPS-treated mouse lung injury, mice were given lipopolysaccharide (LPS) intraperitoneally. The mRNAs for activating transcription factor (ATF) 4 and X-box binding protein (XBP) 1, transcriptional activators of the CHOP gene, and that...

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PMID: 16272146
DOI: 10.1093/jb/mvi143

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