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Article

Activation of AMP-activated protein kinase attenuates ethanol-induced ER/oxidative stress and lipid phenotype in human pancreatic acinar cells.

Biochemical pharmacology - 1 Oct 2020

Srinivasan Mukund P, Bhopale Kamlesh K, Caracheo Anna A, Amer Samir M, Khan Shamis, Kaphalia Lata, Loganathan Gopalakrishnan, Balamurugan Appakalai N, Kaphalia Bhupendra S

Abstract excerpt

Primary toxicity targets of alcohol and its metabolites in the pancreas are cellular energetics and endoplasmic reticulum (ER). Therefore, the role of AMP-Activated Protein Kinase (AMPKα) in amelioration of ethanol (EtOH)-induced pancreatic acinar cell injury including ER/oxidative stress, inflammatory responses, the formation of fatty acid ethyl esters (FAEEs) and mitochondrial bioenergetics were determined in...

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Identifiers

PMID: 32717227
DOI: 10.1016/j.bcp.2020.114174
PMCID: PMC7651864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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