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Article

Neuregulin-1 type III determines the ensheathment fate of axons.

Neuron - 1 Sept 2005

Taveggia Carla, Zanazzi George, Petrylak Ashley, Yano Hiroko, Rosenbluth Jack, Einheber Steven, Xu Xiaorong, Esper Raymond M, Loeb Jeffrey A, Shrager Peter, Chao Moses V, Falls Douglas L, Role Lorna, Salzer James L

Abstract excerpt

The signals that determine whether axons are ensheathed or myelinated by Schwann cells have long been elusive. We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their ensheathment fate. Ensheathed axons express low levels whereas myelinated fibers express high...

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Identifiers

PMID: 16129398
DOI: 10.1016/j.neuron.2005.08.017
PMCID: PMC2387056

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16129398-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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