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Article

Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells.

Development (Cambridge, England) - 1 Nov 2004

Joseph Nancy M, Mukouyama Yoh-Suke, Mosher Jack T, Jaegle Martine, Crone Steven A, Dormand Emma-Louise, Lee Kuo-Fen, Meijer Dies, Anderson David J, Morrison Sean J

Abstract excerpt

Neural crest stem cells (NCSCs) persist in peripheral nerves throughout late gestation but their function is unknown. Current models of nerve development only consider the generation of Schwann cells from neural crest, but the presence of NCSCs raises the possibility of multilineage differentiation. We performed Cre-recombinase fate mapping to determine which nerve cells are neural crest derived. Endoneurial...

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Identifiers

PMID: 15496445
DOI: 10.1242/dev.01429
PMCID: PMC2638001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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