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Article

Modulation of neuroblastoma cell differentiation by the extracellular matrix.

International journal of cancer - 9 Jul 1992

Matsushima H, Bogenmann E

Abstract excerpt

The effect of a complex in vitro synthesized extracellular matrix (ECM) and its components on growth and phenotypical differentiation of a human neuroblastoma (NB) cell line (HTLA230) was investigated. Rat smooth-muscle-cell (R22CIF)-derived ECM composed of collagen, glycoproteins, and glycosaminoglycans (GAGs) promoted spontaneous neurite outgrowth of HTLA230 cells but did not alter their growth kinetic or...

Topics

Animals
Cell Differentiation
Clone Cells
Collagen
Extracellular Matrix
Glycoproteins
Glycosaminoglycans
Humans
Neurites
Neuroblastoma
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tretinoin

Trypsin

Tumor Cells, Cultured

Source

Identifiers

PMID: 1612781
DOI: 10.1002/ijc.2910510511

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1612781-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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