Article
Phenotypic and morphological characterization of neuroblastoma cells constitutively expressing B-myb.
Journal of neuro-oncology - 1 Jan 1997
Scarpa S, Negroni A, Amendola R, Signorelli P, Calabretta B, Modesti A, Raschellà G
Abstract excerpt
B-myb gene is expressed in neuroblastoma cells and down-regulated during differentiation. We used B-myb-transfected LAN-5 cells, which constitutively express high level of B-myb, to detect changes at phenotypic and morphological levels in basal and differentiation conditions. Our results demonstr...
Topics
- Cell Cycle Proteins
- Cell Differentiation
- Cytoskeleton
- DNA-Binding Proteins
- Extracellular Matrix
- Gene Expression Regulation, Neoplastic
- Glial Fibrillary Acidic Protein
- Immunohistochemistry
- Keratins
- Microscopy, Electron
- Neuroblastoma
- Neurofilament Proteins
- Phenotype
- RNA, Messenger
- Trans-Activators
- Transcription Factors
- Transfection
- Tumor Cells, Cultured