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Article

Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children.

Antimicrobial agents and chemotherapy - 1 Sept 2005

Dzinjalamala Fraction K, Macheso Allan, Kublin James G, Taylor Terrie E, Barnes Karen I, Molyneux Malcolm E, Plowe Christopher V, Smith Peter J

Abstract excerpt

Sulfadoxine-pyrimethamine (SP) has been widely used in recent years to treat acute uncomplicated Plasmodium falciparum malaria. Risk factors for SP therapeutic failure include young age, subtherapeutic SP concentrations, and resistance-conferring genetic mutations in parasite target enzymes. A substantial proportion of patients are able to clear genetically highly resistant P. falciparum genotypes. To determine...

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Source

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Identifiers

PMID: 16127028
DOI: 10.1128/AAC.49.9.3601-3606.2005
PMCID: PMC1195435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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