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Article

Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria.

The American journal of tropical medicine and hygiene - 1 Sept 2003

Kyabayinze Daniel, Cattamanchi Adithya, Kamya Moses R, Rosenthal Philip J, Dorsey Grant

Abstract excerpt

Surveillance of molecular markers for key mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) has been proposed as a means of predicting sulfadoxine/ pyrimethamine (SP) treatment outcomes in Africa. This study assessed the association between DHFR and DHPS mutations and standardized clinical outcomes in children treated with SP for uncomplicated malaria in...

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Share to Dihydropteroate Synthase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Outcome Assessment, Health Care

Share to Pyrimethamine

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Share to Tetrahydrofolate Dehydrogenase

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Share to Uganda

Source

Identifiers

PMID: 14628939

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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