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Pregnancy Loss and Endometriosis: Pathogenic Role of Anti-Laminin-1 Autoantibodies

1 Jun 2005

Abstract excerpt

Laminin-1 is a major multifunctional glycoprotein that forms an integral part of the scaffolding network of basement membranes, and is the earliest synthesized component during embryogenesis. This protein (alpha1beta1gamma1) plays an important role in basement membrane assembly and epiblast differentiation during embryonic development. Anti-laminin-1 autoantibodies are known to cause infertility and recurrent...

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Identifiers

PMID: 16126957
DOI: 10.1196/annals.1361.059

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