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Article

&Delta;Np63&alpha; Levels Correlate with Clinical Tumor Response to Cisplatin

23 Sept 2005

Abstract excerpt

After exposure to damaging agents, the p53 tumor suppressor is stabilized mediating cell cycle arrest and apoptosis. p53 family member, DeltaNp63 promotes cell proliferation and accelerates tumor growth. We previously found that the genotoxic stress agents induced a decrease of DeltaNp63alpha. We further observed that genotoxic stress mediated phosphorylation of DeltaNp63alpha targeting it into proteasome...

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Identifiers

PMID: 16123597
DOI: 10.4161/cc.4.10.2066

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