Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation

15 Mar 2012

Abstract excerpt

Cisplatin was shown to induce the ataxia telangiectasia mutated (ATM)-dependent phosphorylation of tumor protein p63 isoform, (ΔNp63α), leading to a transcriptional regulation of specific genes implicated in the control of cell death of squamous cell carcinoma (SCC) cells. We previously observed that the cisplatin-induced phosphorylated (p)-ΔNp63α transcriptionally regulates the expression of specific microRNAs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to MicroRNA in disease regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22356768
DOI: 10.4161/cc.11.6.19670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulationPMID 22356768Read ↗

Phospho-ΔNp63α-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death.Semantic proximity Read ↗

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cellsSemantic proximity Read ↗

Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposureSemantic proximity Read ↗

Global tumor protein p53/p63 interactomeSemantic proximity Read ↗

Phospho‐ΔNp63α regulates <i>AQP3, ALOX12B, CASP14</i> and <i>CLDN1</i> expression through transcription and microRNA modulationSemantic proximity Read ↗

ΔNp63α Confers Tumor Cell Resistance to Cisplatin through the AKT1 Transcriptional RegulationSemantic proximity Read ↗

ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.Semantic proximity Read ↗

TIP60 enhances cisplatin resistance via regulating ΔNp63α acetylation in SCCSemantic proximity Read ↗

Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure.Semantic proximity Read ↗

Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells.Semantic proximity Read ↗

RACK1 and Stratifin Target &Delta;Np63&alpha; for a Proteasome Degradation in Head and Neck Squamous Cell Carcinoma Cells upon DNA DamageSemantic proximity Read ↗

ΔNp63α Transcriptionally Represses p53 Target Genes Involved in the Radiation-Induced DNA Damage ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.