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Article

Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure.

Cell cycle (Georgetown, Tex.) - 15 Jan 2010

Huang Yiping, Chuang Alice Y, Romano Rose-Anne, Liégeois Nanette J, Sinha Satrajit, Trink Barry, Ratovitski Edward, Sidransky David

Abstract excerpt

Cisplatin remains the most important chemotherapeutic agent for patients with human head and neck cancer. However, tumor cells often develop resistance to cisplatin-induced apoptosis. We previously found that head and neck squamous cell carcinoma (HNSCC) cells exposed to cisplatin display a marked ATM-induced phosphorylation of DeltaNp63alpha. However, the mutated Np63-S385G failed to undergo phosphorylation by...

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Source

Identifiers

PMID: 20023394
DOI: 10.4161/cc.9.2.10432

Genes

ATM
DDIT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure.PMID 20023394Read ↗

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