Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure

15 Nov 2011

Abstract excerpt

The cisplatin-induced ATM-dependent phosphorylated (p)-ΔNp63α plays an important role in transcriptional regulation of specific genes encoding mRNAs and microRNAs (miRs) implicated in cell death, cell survival, and chemoresistance. The p-ΔNp63α-induced miR-885-3p functions as a critical regulator of MDM4, ATK1, BCL2, ATG16L2, ULK2, CASP2, and CASP3 mRNAs via pairing with their respective 'recognition' sequences....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to MicroRNA in disease regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22071691
DOI: 10.4161/cc.10.22.18107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposurePMID 22071691Read ↗

Global tumor protein p53/p63 interactomeSemantic proximity Read ↗

Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulationSemantic proximity Read ↗

Phospho-ΔNp63α-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death.Semantic proximity Read ↗

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cellsSemantic proximity Read ↗

Phospho‐ΔNp63α regulates <i>AQP3, ALOX12B, CASP14</i> and <i>CLDN1</i> expression through transcription and microRNA modulationSemantic proximity Read ↗

ΔNp63α in cancer: importance and therapeutic opportunitiesSemantic proximity Read ↗

ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage.Semantic proximity Read ↗

miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced CytotoxicitySemantic proximity Read ↗

Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responsesSemantic proximity Read ↗

Interplay of p62-mTORC1 and EGFR signaling promotes cisplatin resistance in oral cancerSemantic proximity Read ↗

ΔNp63α Confers Tumor Cell Resistance to Cisplatin through the AKT1 Transcriptional RegulationSemantic proximity Read ↗

“Two hits - one stone”; increased efficacy of cisplatin-based therapies by targeting PCNA’s role in both DNA repair and cellular signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.