Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2005

Hoffmann Erich, Lipatov Aleksandr S, Webby Richard J, Govorkova Elena A, Webster Robert G

Abstract excerpt

If H5N1 influenza viruses become transmissible among humans, vaccination will offer the most effective option to limit their spread. Two human vaccine candidates recently generated by reverse genetics are based on antigenically different hemagglutinin (HA) glycoproteins derived from the A/HK/213/03 (H5N1) and A/Vietnam/1203/04 (H5N1) viruses. Their HA1 amino acid sequences differ at 10 positions, one of which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to Ferrets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza Vaccines

Share to Neutralization Tests

Share to Orthomyxoviridae

Share to Orthomyxoviridae Infections

Share to Protein Structure, Quaternary

Source

Open in PubMed Open full text

Identifiers

PMID: 16118277
DOI: 10.1073/pnas.0506416102
PMCID: PMC1200312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines.PMID 16118277Read ↗

Cross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/97(H5) vaccines against infection with A/Vietnam/1203/04(H5N1) virus in ferrets.Semantic proximity Read ↗

Immunization with Reverse‐Genetics–Produced H5N1 Influenza Vaccine Protects Ferrets against Homologous and Heterologous ChallengeSemantic proximity Read ↗

Recombinant Modified Vaccinia Virus Ankara Expressing the Hemagglutinin Gene Confers Protection against Homologous and Heterologous H5N1 Influenza Virus Infections in MacaquesSemantic proximity Read ↗

Amino Acid Residue 217 in the Hemagglutinin Glycoprotein Is a Key Mediator of Avian Influenza H7N9 Virus AntigenicitySemantic proximity Read ↗

Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.Semantic proximity Read ↗

Antigenic variation of H1N1, H1N2 and H3N2 swine influenza viruses in Japan and Vietnam.Semantic proximity Read ↗

Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman PrimatesSemantic proximity Read ↗

Epitope Mapping of the Hemagglutinin Molecule of a Highly Pathogenic H5N1 Influenza Virus by Using Monoclonal AntibodiesSemantic proximity Read ↗

Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014-2015 Influenza Season.Semantic proximity Read ↗

The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.Semantic proximity Read ↗

Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus ChallengeSemantic proximity Read ↗

Live, Attenuated Influenza A H5N1 Candidate Vaccines Provide Broad Cross-Protection in Mice and FerretsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.