Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The photocarcinogenesis of antibiotic lomefloxacin and UVA radiation is enhanced in xeroderma pigmentosum group A gene-deficient mice.

The Journal of investigative dermatology - 1 Sept 2005

Itoh Taketo, Miyauchi-Hashimoto Hiroko, Sugihara Akira, Tanaka Kiyoji, Horio Takeshi

Abstract excerpt

Lomefloxacin (LFLX) is phototoxic and phototumorigenic, but the mechanisms of phototumorigenesis of quinolone drugs have not been fully elucidated. Formation of cyclobutane pyrimidine dimers (CPD) by UVB radiation is primarily involved in the carcinogenesis of ultraviolet (UV) radiation. On the other hand, UVA region is responsible to photobiologic reactions of quinolone drugs. To know if CPD can be formed by UVA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to Fluoroquinolones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms, Radiation-Induced

Share to Photosensitizing Agents

Share to Pyrimidine Dimers

Share to Quinolones

Share to Ultraviolet Rays

Share to Xeroderma Pigmentosum Group A Protein

Source

Identifiers

PMID: 16117798
DOI: 10.1111/j.0022-202X.2005.23862.x

Genes

XPA
CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

The photocarcinogenesis of antibiotic lomefloxacin and UVA radiation is enhanced in xeroderma pigmentosum group A gene-deficient mice.PMID 16117798Read ↗

Molecular Responses to Photogenotoxic Stress Induced by the Antibiotic Lomefloxacin in Human Skin Cells: From DNA Damage to ApoptosisSemantic proximity Read ↗

Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC.Semantic proximity Read ↗

UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.Semantic proximity Read ↗

Formation of Cyclobutane Pyrimidine Dimers after UVA Exposure (Dark-CPDs) Is Inhibited by an Hydrophilic Extract of Polypodium leucotomosSemantic proximity Read ↗

Immunoexpression of ultraviolet photoproducts and p53 mutation analysis in atypical fibroxanthoma and superficial malignant fibrous histiocytoma.Semantic proximity Read ↗

Light-dependent mutagenesis by benzo[a]pyrene is mediated via oxidative DNA damage.Semantic proximity Read ↗

Differences in the photogenotoxic potential of two fluoroquinolones as shown in diploid yeast strain (Saccharomyces cerevisae) and supercoiled plasmid DNA.Semantic proximity Read ↗

An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium.Semantic proximity Read ↗

Mutagenicity of photodynamic therapy as compared to UVC and ionizing radiation in human and murine lymphoblast cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.