Article
An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium.
Molecular vision - 8 Apr 2010
Tung Jai-Nien, Wu Heng-Hsiung, Chiang Chun-Chi, Tsai Yi-Yu, Chou Ming-Chih, Lee Huei, Cheng Ya-Wen
Abstract excerpt
PURPOSE: Benzo[a]pyrene 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo[a]pyrene, attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations. Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the met...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Aged
- Aged, 80 and over
- Cytochrome P-450 CYP1A1
- DNA Adducts
- Epithelial Cells
- Female
- Genetic Predisposition to Disease
- Glutathione Transferase
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length