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Article

A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT.

Oncogene - 24 Nov 2005

Cerone Maria A, Autexier Chantal, Londoño-Vallejo J Arturo, Bacchetti Silvia

Abstract excerpt

In human somatic cells proliferation results in telomere shortening due to the end replication problem and the absence of adequate levels of telomerase activity. The progressive loss of telomeric DNA has been associated with replicative senescence. Maintenance of telomere structure and function is, therefore, an essential requisite for cells that proliferate indefinitely. Human cells that have acquired the...

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PMID: 16116482
DOI: 10.1038/sj.onc.1208934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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