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Article

Alternative Lengthening of Telomeres in Human Cells

1 Jan 2001

Abstract excerpt

Reddel, R. R., Bryan, T. M., Colgin, L. M., Perrem, K. T. and Yeager, T. R. Alternative Lengthening of Telomeres in Human Cells.Activation of a telomere maintenance mechanism appears to be essential for immortalization. In most human tumors and tumor cell lines, the telomere maintenance mechanism involves the activity of telomerase, a reverse transcriptase holoenzyme that synthesizes telomeric repeat DNA. In some...

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Share to Advanced biosensing and bioanalysis techniques
Share to RNA Interference and Gene Delivery
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 11121234
DOI: 10.1667/0033-7587(2001)155[0194:alotih]2.0.co;2

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