Article
Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jan 1996
Ghetti B, Piccardo P, Spillantini M G, Ichimiya Y, Porro M, Perini F, Kitamoto T, Tateishi J, Seiler C, Frangione B, Bugiani O, Giaccone G, Prelli F, Goedert M, Dlouhy S R, Tagliavini F
Abstract excerpt
Deposition of PrP amyloid in cerebral vessels in conjunction with neurofibrillary lesions is the neuropathologic hallmark of the dementia associated with a stop mutation at codon 145 of PRNP, the gene encoding the prion protein (PrP). In this disorder, the vascular amyloid in tissue sections and...
Topics
- Adult
- Amyloid
- Blood Vessels
- Cerebral Amyloid Angiopathy
- Cerebral Cortex
- Dementia
- Female
- Humans
- Japan
- Mutation
- Neurons
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length