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Article

Glucocorticoids: Effects on Gene Transcription

1 Nov 2004

Abstract excerpt

The major antiinflammatory effects of glucocorticoids appear to be due largely to interaction between the activated glucocorticoid receptor and transcription factors, notably nuclear factor-kappaB (NF-kappaB) and activator protein-1, that mediate the expression of inflammatory genes. NF-kappaB switches on inflammatory genes via a process involving recruitment of transcriptional coactivator proteins and changes in...

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PMID: 16113442
DOI: 10.1513/pats.200402-001ms

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