Article
Promoter hypermethylation of tetraspanin members contributes to their silencing in myeloma cell lines
20 Aug 2005
Abstract excerpt
Multiple myeloma (MM) cell interactions with their microenvironment modulate acquired drug resistance and disease progression. Indeed, reported aberrant gene methylation underscores the possible role of epigenetic events in MM's molecular profile. Membranal tetraspanins are often inversely correlated with cancer prognosis and metastasis, however mutations were unidentified hitherto. Their promoter characteristics...
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