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Article

Genetic variation, nucleotide diversity, and linkage disequilibrium in seven telomere stability genes suggest that these genes may be under constraint.

Human mutation - 1 Oct 2005

Savage Sharon A, Stewart Brian J, Eckert Andrew, Kiley Maureen, Liao Jason S, Chanock Stephen J

Abstract excerpt

To maintain chromosomal integrity and to protect the ends of chromosomes against recognition as damaged DNA, end-to-end fusion, or recombination, a coordinated set of genes is required to stabilize the telomere. We surveyed common genetic variation in seven genes that are vital to telomere stability (TERT, POT1, TNKS, TERF1, TINF2, TERF2, and TERF2IP) and validated single nucleotide polymorphisms (SNPs) in four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16110488
DOI: 10.1002/humu.20226

Genes

POT1
TERT
TINF2
TNKS

Provenance

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