Bayesian methods for fitting mixture models that characterize branching tree processes: An application to development of resistant TB strains.

Abstract excerpt

For pathogens that must be treated with combinations of antibiotics and acquire resistance through genetic mutation, knowledge of the order in which drug-resistance mutations occur may be important for determining treatment policies. Diagnostic specimens collected from patients are often available; this makes it possible to determine the presence of individual drug resistance-conferring mutations and combinations...

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