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Article

Nucleophile selectivity in the acyl transfer reaction of a designed enzyme.

Biopolymers - 15 Dec 2005

Hederos Sofia, Baltzer Lars

Abstract excerpt

The acyl transfer reaction of S-glutathionyl benzoate (GSB) is catalyzed by a rationally designed mutant of human glutathione transferase A1-1, A216H. The catalyzed reaction proceeds via the formation of an acyl intermediate and has been studied in the presence of nitrogen, oxygen, and sulfur nucleophiles to determine the selectivity with regards to nucleophile structure. Methanol was previously shown to react...

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Identifiers

PMID: 16108014
DOI: 10.1002/bip.20351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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