Article
A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation.
Genes & development - 15 Nov 1998
Chung C Y, Reddy T B, Zhou K, Firtel R A
Abstract excerpt
We have identified a developmentally regulated, putative MEK kinase (MEKKalpha) that contains an F-box and WD40 repeats and plays a complex role in regulating cell-type differentiation and spatial patterning. Cells deficient in MEKKalpha develop precociously and exhibit abnormal cell-type pattern...
Topics
- Amino Acid Sequence
- Animals
- Body Patterning
- Cell Differentiation
- Chimera
- Cloning, Molecular
- Dictyostelium
- Fluorescent Antibody Technique
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Ligases
- Molecular Sequence Data
- Morphogenesis
- Mutation
- Protein Serine-Threonine Kinases