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Article

Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster.

Molecular and cellular biology - 1 Sept 2005

Gerber Mark A, Shilatifard Ali, Eissenberg Joel C

Abstract excerpt

The ELL family of proteins function in vitro as elongation factors for RNA polymerase II. Deletion studies have defined domains in mammalian ELL required for transcription elongation activity and RNA polymerase binding in vitro, for transformation of cultured cells when overexpressed, and for leukemogenesis and cell proliferation as part of a leukemic fusion protein. The goal of this study was to identify domains...

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Identifiers

PMID: 16107725
DOI: 10.1128/MCB.25.17.7803-7811.2005
PMCID: PMC1190276

Genes

ELL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Mutational analysis of an RNA polymerase II elongation factor in Drosophila melanogaster.PMID 16107725Read ↗

dELL is an essential RNA polymerase II elongation factor with a general role in development.Semantic proximity Read ↗

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