Article
Targeting and trafficking of the human thiamine transporter-2 in epithelial cells.
The Journal of biological chemistry - 24 Feb 2006
Subramanian Veedamali S, Marchant Jonathan S, Said Hamid M
Abstract excerpt
Humans lack biochemical pathways for thiamine synthesis, so cellular requirements are met via specific carrier-mediated uptake pathways. Two proteins from the solute carrier SLC19A gene family have been identified as human thiamine transporters (hTHTRs), SLC19A1 (hTHTR1) and SLC19A2 (hTHTR2). Both of these transporters are co-expressed but are differentially targeted in polarized cell types that mediate vectorial...
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