Article
Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene.
Biochemical and biophysical research communications - 7 Oct 2005
Coia Valentina, Jüliger Simone, Mordmüller Benjamin, Kreidenweis Andrea, Stroh Anna-Lena, Ortega Claudia, Vindigni Alessandro, Dengjel Jörn, Lukyanov Dmitry V, Destro-Bisol Giovanni, Fedorov Anton, Podgornaya Olga I, Kun Jürgen F J
Abstract excerpt
A point mutation (G --> C) in the gene promoter for the human nitric oxide synthase (NOS) 2 at position -954 is associated with protection against severe Plasmodium falciparum malaria in Gabon. Carriers of this mutation show higher basal levels of nitric oxide production than wild type individuals. To obtain information about the possible binding transcription factors, nucleic proteins from the lung carcinoma...
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