Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delineation and molecular characterization of acute myeloid leukemia patients with coduplication of FLT3 and MLL.

European journal of haematology - 1 Sept 2005

Olesen Lene Hyldahl, Nyvold Charlotte Guldborg, Aggerholm Anni, Nørgaard Jan Maxwell, Guldberg Per, Hokland Peter

Abstract excerpt

Partial tandem (PTD) and internal tandem duplications (ITD) of the MLL or FLT3 genes respectively, have been demonstrated in acute myeloid leukemia (AML). While occurrence of each of these PTD/ITD seem to confer an unfavorable prognosis, the literature contains only sparse information of the occurrence and the prognosis of simultaneous PTD/ITD of these genes. We have therefore attempted to determine the presence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid

Share to Myeloid-Lymphoid Leukemia Protein

Share to Proto-Oncogenes

Share to Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 16104873
DOI: 10.1111/j.1600-0609.2005.00502.x

Genes

FLT3
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delineation and molecular characterization of acute myeloid leukemia patients with coduplication of FLT3 and MLL.PMID 16104873Read ↗

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia.Semantic proximity Read ↗

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines.Semantic proximity Read ↗

The MLL partial tandem duplication in acute myeloid leukaemia.Semantic proximity Read ↗

Immunophenotypic findings in acute myeloid leukemia with FLT3 internal tandem duplication.Semantic proximity Read ↗

Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23.Semantic proximity Read ↗

Internal tandem duplications of the FLT3 and MLL genes are mainly observed in atypical cases of therapy-related acute myeloid leukemia with a normal karyotype and are unrelated to type of previous therapy.Semantic proximity Read ↗

High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis.Semantic proximity Read ↗

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trialsSemantic proximity Read ↗

Molecular typing of adult acute myeloid leukaemia: significance of translocations, tandem duplications, methylation, and selective gene expression profilingSemantic proximity Read ↗

Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: a study of the Japanese childhood AML Cooperative Study Group.Semantic proximity Read ↗

Prognostic significance of foetal-like tyrosine kinase 3 mutation in Egyptian children with acute leukaemia.Semantic proximity Read ↗

Acute myelogenous leukemia with internal tandem duplication of the Flt3 gene appearing or altering at the time of relapse: a report of two cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.