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Article

New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2005

Nicchia Grazia P, Srinivas Miduturu, Li Wei, Brosnan Celia F, Frigeri Antonio, Spray David C

Abstract excerpt

Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes of mouse, rat, and human astrocytes. In a previous study, we used small interfering RNA (siRNA) to specifically knock down AQP4 in rat astrocyte primary cultures and found that together with reduced osmotic permeability, AQP4 knockdown (KD) led to altered cell morphology. However, a recent report on primary...

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Source

Identifiers

PMID: 16103109
DOI: 10.1096/fj.04-3281fje

Genes

AQP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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