BRCA1 variants in a family study of African-American and Latina women.

doi:10.1007/s00439-004-1240-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

BRCA1 variants in a family study of African-American and Latina women.

Human genetics - 1 May 2005

McKean-Cowdin Roberta, Spencer Feigelson Heather, Xia Lucy Y, Pearce Celeste Leigh, Thomas Duncan C, Stram Daniel O, Henderson Brian E

Abstract excerpt

We sequenced the entire coding region of BRCA1 to improve our understanding of the frequency and nature of BRCA1 variants in African-American and Latina women identified from a multiethnic cohort in Los Angeles, California. The study included 109 African-American and 140 Latina sibships from families with two or more cases of breast or ovarian cancer among first-degree relatives. BRCA1 was sequenced in 278 breast...

Topics

Adult
Black or African American
Aged
Breast Neoplasms
Chromosome Mapping
Cohort Studies
Family Health
Female
Gene Frequency
Genes, BRCA1
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hispanic or Latino

Humans

Middle Aged

Mutation

Ovarian Neoplasms

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 15726418
DOI: 10.1007/s00439-004-1240-5

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1 variants in a family study of African-American and Latina women.PMID 15726418Read ↗

The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective.Semantic proximity Read ↗

BRCA1 and BRCA2 mutations in a study of African American breast cancer patients.Semantic proximity Read ↗

Breast cancer genetics in African Americans.Semantic proximity Read ↗

Prevalence of BRCA1 and BRCA2 mutations among clinic-based African American families with breast cancer.Semantic proximity Read ↗

A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk.Semantic proximity Read ↗

BRCA1 and BRCA2 pathogenic sequence variants in women of African origin or ancestry.Semantic proximity Read ↗

Genetic Epidemiology of Breast Cancer in Latin America.Semantic proximity Read ↗

Inherited predisposition to breast cancer among African American women.Semantic proximity Read ↗

Frequency and spectrum of mutations across 94 cancer predisposition genes in African American women with invasive breast cancer.Semantic proximity Read ↗

Hereditary variants of unknown significance in African American women with breast cancer.Semantic proximity Read ↗

Understanding germ-line mutations in BRCA1.Semantic proximity Read ↗

Expanding BRCA1/BRCA2 genomic diversity in the Caribbean: insights from the first national cohort in the Dominican RepublicSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.