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Article

OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.

Cancer research - 15 Aug 2005

Lin Ying-Wei, Deveney Ramona, Barbara Mary, Iscove Norman N, Nimer Stephen D, Slape Christopher, Aplan Peter D

Abstract excerpt

OLIG2 (originally designated BHLHB1) encodes a transcription factor that contains the basic helix-loop-helix motif. Although expression of OLIG2 is normally restricted to neural tissues, overexpression of OLIG2 has been shown in patients with precursor T-cell lymphoblastic lymphoma/leukemia (pre-T LBL). In the current study, we found that overexpression of OLIG2 was not only found in oligodendroglioma samples and...

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Source

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Identifiers

PMID: 16103065
DOI: 10.1158/0008-5472.CAN-05-1400
PMCID: PMC1681523

Genes

OLIG2
LMO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.PMID 16103065Read ↗

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct PathwaysSemantic proximity Read ↗

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALLSemantic proximity Read ↗

Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma.Semantic proximity Read ↗

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.Semantic proximity Read ↗

Head of the Class: OLIG2 and Glioblastoma Phenotype.Semantic proximity Read ↗

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in MiceSemantic proximity Read ↗

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.Semantic proximity Read ↗

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNSSemantic proximity Read ↗

Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specificationSemantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

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