Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors

Abstract excerpt

Meningiomas account for one-third of all primary brain tumors. Although typically benign, about 20% of meningiomas are aggressive, and despite the rigor of the current histopathological classification system, there remains considerable uncertainty in predicting tumor behavior. Here, we analyzed 160 tumors from all three WHO grades (I-III) using clinical, gene expression and sequencing data. Unsupervised clustering...

Topics

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• Bone Tumor Diagnosis and Treatments
• Data Analysis
• DNA Methylation
• Drug Discovery
• Glioma Diagnosis and Treatment
• Meningioma
• Meningioma and schwannoma management
• Neurofibromatosis and Schwannoma Cases

Identifiers and source

Literature Corpus work

f9ced408-83fb-541e-9cb1-113ef29ae2df

DOI

10.1101/679480