Article
Rudimentary claws and pigmented nail-like structures on the distal tips of the digits of Wnt7a mutant mice: Wnt7A suppresses nail-like structure development in mice.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2010
Kimura Sumiko, Saitsu Hirotomo, Schaumann Blanka A, Shiota Kohei, Matsumoto Naomichi, Ishibashi Makoto
Abstract excerpt
BACKGROUND: As Wnt7a mutant mice exhibit double ventral structures in the digits of autopods, it has been accepted that dorsal-ventral identity in limb development is regulated by the Wnt7a signal. The most important evidence for this was the presence of surface pads, typical characteristics of ventral structures, on the dorsal side of digital tips and at the base of digits and their pigmentation. METHODS: The...
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