Article
Effect of prostaglandin E2 on cyclic AMP levels in limb cells of mouse mutant brachypodism.
Developmental biology - 1 Dec 1990
Ballard T A, Elmer W A
Abstract excerpt
Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 but in the presence of the phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (MIX), the...
Topics
- 1-Methyl-3-isobutylxanthine
- Alleles
- Animals
- Blastocyst
- Cell Differentiation
- Cyclic AMP
- Dinoprostone
- Hindlimb
- Mice
- Mutation