Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2009

Kiser Philip D, Golczak Marcin, Lodowski David T, Chance Mark R, Palczewski Krzysztof

Abstract excerpt

Vertebrate vision is maintained by the retinoid (visual) cycle, a complex enzymatic pathway that operates in the retina to regenerate the visual chromophore, 11-cis-retinal. A key enzyme in this pathway is the microsomal membrane protein RPE65. This enzyme catalyzes the conversion of all-trans-retinyl esters to 11-cis-retinol in the retinal pigment epithelium (RPE). Mutations in RPE65 are known to be responsible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blindness
Share to Carotenoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Cattle

Share to Eye Proteins

Share to Retinal Pigment Epithelium

Share to Vision, Ocular

Source

Open in PubMed Open full text

Identifiers

PMID: 19805034
DOI: 10.1073/pnas.0906600106
PMCID: PMC2765077

Genes

RPE65
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of native RPE65, the retinoid isomerase of the visual cycle.PMID 19805034Read ↗

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.Semantic proximity Read ↗

Human cone photoreceptor dependence on RPE65 isomeraseSemantic proximity Read ↗

Temperature-sensitive retinoid isomerase activity of RPE65 mutants associated with Leber Congenital Amaurosis.Semantic proximity Read ↗

Impact of retinal disease-associated RPE65 mutations on retinoid isomerization.Semantic proximity Read ↗

Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy.Semantic proximity Read ↗

Novel RPE65 mutations associated with Leber congenital amaurosis in Chinese patients.Semantic proximity Read ↗

A History of the Classical Visual Cycle.Semantic proximity Read ↗

A heterozygous pathogenic RPE65 variant phenocopies a mitochondrial retinopathy.Semantic proximity Read ↗

Pathways and disease-causing alterations in visual chromophore production for vertebrate visionSemantic proximity Read ↗

Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy.Semantic proximity Read ↗

<i>RPE65</i> knockout <i>Xenopus laevis</i> have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersionSemantic proximity Read ↗

Personalized Pathogenicity Assessment of RPE65 Gene Mutations Using Patient-Specific hiPSC-Derived Retinal Pigment Epithelium Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.