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Article

Progressive alterations in global and GC-rich DNA methylation during tumorigenesis.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Oct 2003

Watson Rebecca E, Curtin Geoffrey M, Doolittle David J, Goodman Jay I

Abstract excerpt

DNA methylation plays a key role in the regulation of gene expression, and failure to maintain normal patterns of methylation often contributes to carcinogenesis. We have characterized progressive methylation changes during the promotion stage of carcinogenesis using a SENCAR mouse skin initiation/promotion tumorigenesis model. Mice were initiated with a dermal application of 75 microg dimethylbenz[a]anthracene...

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PMID: 12883089
DOI: 10.1093/toxsci/kfg190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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