Article
Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia.
Leukemia - 1 Nov 2005
Meng Y-S, Khoury H, Dick J E, Minden M D
Abstract excerpt
The LYL1 gene encodes a basic helix-loop-helix transcription factor involved in T-cell acute lymphoblastic leukemia. Using real-time quantitative RT-PCR assay, we found that the expression of LYL1 was at higher levels in the majority cases of acute myeloblastic leukemia (AML) or myelodysplastic syndrome when compared to normal bone marrow. Our study also showed that LYL1 was highly expressed in most AML cell...
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